2-Furoic piperazide derivatives as promising drug candidates of type 2 diabetes and Alzheimer's diseases: In vitro and in silico studies

Muhammad Athar Abbasi, Mubashir Hassan, Aziz ur-Rehman, Sabahat Zahra Siddiqui, Ghulam Hussain, Syed Adnan Ali Shah, Muhammad Ashraf, Muhammad Shahid, Sung Yum Seo

Research output: Contribution to journalArticle

Abstract

The heterocyclic compounds have been extensively reported for their bioactivity potential. The current research work reports the synthesis of some new multi-functional derivatives of 2-furoic piperazide (1; 1-(2-furoyl)piperazine). The synthesis was initiated by reacting the starting compound 1 with 3,5-dichloro-2-hydroxybenzenesulfonyl chloride (2) in a basic, polar and protic medium to obtain the parent sulfonamide 3 which was then treated with different electrophiles, 4a–g, in a polar and aprotic medium to acquire the designed molecules, 5a–g. These convergent derivatives were evaluated for their inhibitory potential against α-glucosidase, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. Acarbose was used as a reference standard for α-glucosidase inhibition while eserine for AChE and BChE inhibition. Some of the synthesized compounds were identified as promising inhibitors of these three enzymes and their bioactivity potentials were also supported by molecular docking study. The most active compounds among the synthetic analogues might be helpful in drug discovery and development for the treatment of type 2 diabetes and Alzhiemer's diseases.

LanguageEnglish
Pages72-86
Number of pages15
JournalComputational Biology and Chemistry
Volume77
DOIs
Publication statusPublished - Dec 1 2018

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Butyrylcholinesterase
Alzheimer's Disease
alpha-Glucosidases
Diabetes
Acetylcholinesterase
Medical problems
Bioactivity
Computer Simulation
Type 2 Diabetes Mellitus
Alzheimer Disease
Drugs
Enzymes
Synthesis
Acarbose
Molecular Docking
Derivatives
Heterocyclic Compounds
Derivative
Physostigmine
Drug Discovery

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Biochemistry
  • Organic Chemistry
  • Computational Mathematics

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2-Furoic piperazide derivatives as promising drug candidates of type 2 diabetes and Alzheimer's diseases : In vitro and in silico studies. / Abbasi, Muhammad Athar; Hassan, Mubashir; ur-Rehman, Aziz; Siddiqui, Sabahat Zahra; Hussain, Ghulam; Ali Shah, Syed Adnan; Ashraf, Muhammad; Shahid, Muhammad; Seo, Sung Yum.

In: Computational Biology and Chemistry, Vol. 77, 01.12.2018, p. 72-86.

Research output: Contribution to journalArticle

Abbasi, Muhammad Athar ; Hassan, Mubashir ; ur-Rehman, Aziz ; Siddiqui, Sabahat Zahra ; Hussain, Ghulam ; Ali Shah, Syed Adnan ; Ashraf, Muhammad ; Shahid, Muhammad ; Seo, Sung Yum. / 2-Furoic piperazide derivatives as promising drug candidates of type 2 diabetes and Alzheimer's diseases : In vitro and in silico studies. In: Computational Biology and Chemistry. 2018 ; Vol. 77. pp. 72-86.
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